Figure 4
From: Pubertal Expression of α4βδ GABAA Receptors Reduces Seizure-Like Discharges in CA1 Hippocampus
Blockade of α5-GABARs has no effect on spontaneous discharge in high K+ at puberty.
(a) Representative traces of spontaneous synchronized activity recorded in 8.5 mM K+ from pubertal CA1 hippocampus before (left) and after (right) 50 nM L-655,708 (L-655) to block α5-GABARs. (b) Expanded time-base of the traces presented in (a). (*individual event from indicated trace) (c), Averaged values of the coastline length. (d) Averaged ratios of the coastline length (CLL) after L-655 relative to the pre-drug control. n = 12 slices from 6 mice/group.
