Table 1 Effects of GABAergic agonists, antagonists and modulators on the frequency and amplitude of spontaneous activity in a high K+ seizure model at puberty.

From: Pubertal Expression of α4βδ GABAA Receptors Reduces Seizure-Like Discharges in CA1 Hippocampus

Drug group

n

Frequency

(Hz)

t

P

Amplitude

(mV)

t

P

Pre-drug

Post-drug

Pre-drug

Post-drug

THIP

17

0.33 ± 0.04

0.28 ± 0.03

3.3

0.002*

1.64 ± 0.17

1.39 ± 0.17

5.5

<0001*

DS2

24

0.34 ± 0.03

0.32 ± 0.03

4.0

0.0003*

1.27 ± 0.16

1.13 ± 0.16

6.19

<0001*

L655

14

0.43 ± 0.45

0.41 ± 0.43

1.6

0.93

1.53 ± 0.17

1.48 ± 0.19

0.69

0.75

SR95531

16

0.40 ± 0.05

0.39 ± 0.04

0.51

0.69

1.61 ± 0.30

1.97 ± 0.38

2.23

0.04*

  1. Mean ± S.E.M., frequency and amplitude of spontaneous activity recorded before and after bath perfusion of the indicated drugs. δ-selective drugs significantly decreased both the frequency and amplitude of spontaneous spiking, while a selective inverse agonist at α5 GABARs, L-655,708 (L655) had no effect. Selectively blocking synaptic inhibition with 200 nM SR9551 had no effect of frequency but significantly increased the amplitude of spontaneous events.
  2. *Denotes statistical significance (1-tail paired t-test).
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