Figure 6
The proposed model of EtOH-induced and NMIIA-mediated Golgi disorganization in hepatocytes.
Under normal conditions, Giantin dimerization maintains Golgi integrity. EtOH treatment induces dedimerization of both giantin8 and Rab6a and results in phosphorylation of NMIIA in S1943. NMIIA-P-S1943 competes with giantin for Rab6a GTPase and is recruited to the Golgi, likely through complex with the cytoplasmic tail of Golgi enzymes. The link NMIIA-Golgi enzymes provides a force for Golgi fragmentation.
