Figure 1: HOTAIR acts as an oncogene in PTC.
From: Onco-lncRNA HOTAIR and its functional genetic variants in papillary thyroid carcinoma
(A) HOTAIR RNA expression detected in 60 pairs of PTC tissue specimens and normal tissues. (B) Ectopically expressed HOTAIR could significantly stimulate cell viability in BCPAP cells. (C) Depletion of HOTAIR expression in BCPAP cells significantly inhibited cell proliferation. (D) Over-expression of lncRNA HOTAIR could significantly promote cell growth of HEK293 cells. (E) Colony formation assays. At the 13rd day after transfection of the HOTAIR expression construct or pcDNA3.1 vector, cells were washed with cold PBS twice and fixed with 3.7% formaldehyde. All experiments were performed in triplicates in three independent transfection experiments and each value represents mean ± SD. **P < 0.01.
