Table 4 Association between HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A, SALL1 according to the presence/absence of CV events or subclinical atherosclerosis in RA patients.

From: Influence of elevated-CRP level-related polymorphisms in non-rheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis

 

Change

Presence/absence of CV events (n = 2,313)

Presence/absence of carotid plaques (n = 1,298)

cIMT (n = 1,298)

P*

HR

[95% CI]*

P**

OR

[95% CI]**

P***

HNF1A rs1183910

G/A

0.96

0.99

[0.73–1.36]

0.55

0.93

[0.73–1.18]

0.63

LEPR rs4420065

C/T

0.24

1.19

[0.89–1.58]

0.57

0.94

[0.75–1.18]

0.54

GCKR rs1260326

C/T

0.51

0.91

[0.68–1.21]

0.36

1.11

[0.89–1.38]

0.35

NLRP3 rs12239046

C/T

0.72

0.95

[0.71–1.27]

0.19

0.86

[0.69–1.08]

0.57

IL1F10 rs6734238

A/G

0.88

0.98

[0.74–1.30]

0.17

1.17

[0.94–1.46]

0.34

PPP1R3B rs9987289

G/A

0.55

0.84

[0.46–1.52]

0.60

0.89

[0.59–1.36]

0.19

ASCL1 rs10745954

A/G

0.81

1.04

[0.78–1.38]

0.67

0.95

[0.76–1.19]

0.92

HNF4A rs1800961

C/T

0.32

1.51

[0.67–3.43]

0.50

1.27

[0.63–2.60]

0.72

SALL1 rs10521222

C/T

0.97

1.01

[0.53–1.91]

0.58

0.87

[0.53–1.43]

0.75

  1. CV: cardiovascular; RA: rheumatoid arthritis; cIMT: carotid intima-media thickness; HR: hazard ratios; CI: confidence interval; OR: odds ratio. *Adjustment for gender, follow-up time, age at RA diagnosis and traditional CV risk factors by Cox regression. **Adjustment for gender, follow-up time, age at the time of ultrasonography study and traditional CV risk factors by logistic regression. ***Adjustment for gender, follow-up time, age at the time of ultrasonography study and traditional CV risk factors using analysis of covariance (ANCOVA).
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