Figure 1
From: Modulation of IL-6 induced RANKL expression in arthritic synovium by a transcription factor SOX5
Increased expression levels of SOX5 in RA synovium.
(A) Real-time-PCR analysis of SOX5 expression in synovium from RA (n = 20) and OA (n = 20) patients. (B) ELISA analysis of SOX5 levels in synovial fluid from RA (n = 30) and OA (n = 27) patients. (C) Representative images of RA (upper) and OA (lower) synovium immunostained for SOX5 (n = 5, respectively). (D) Real-time PCR analysis of Sox5 expression in arthritic joint of CIA mice and normal control (NC) mice (n = 10 mice per group). (E) Immunohistochemical detection of SOX5 expression in the synovium from CIA (upper) and NC (lower) mice (n = 5, respectively). (F) Percentage of SOX5 positive area in synovium from human RA, OA, CIA mouse and NC. Values are means ± SD. Scale bar, 100 μm. R.E, Relative expression.
