Figure 5: RCM treatment enhances adult neurogenesis. | Scientific Reports

Figure 5: RCM treatment enhances adult neurogenesis.

From: Neural stem cells secrete factors facilitating brain regeneration upon constitutive Raf-Erk activation

Figure 5

(A) Schematic presentation of the experimental procedure. RCM-effects on SVZ-NSC proliferation and neurogenesis were assessed in brains of adult mice. CM was infused into the right lateral ventricle (LV) using an osmotic pump. Six days after CM infusion, activated B-type (B–E), C-type (F–I), and A type cells (neuroblasts) (J–M) in the ipsilateral SVZs and A-type cells of the RMS (N-Q) were assessed. Brain regions analyzed are indicated with dotted boxes in the right schematic of ‘(A)’. Cerebrospinal fluid (CSF) was infused into the control mice. Significantly different from the CSF-infused control* and from CCM-infused # at p < 0.005, one-way ANOVA, n = 4 (CSF), 7 (CCM), and 7 animals (RCM).

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