Figure 7: CsA and FK506 inhibit PAN-induced podocyte apoptosis in cultured mouse podocytes in vitro. | Scientific Reports

Figure 7: CsA and FK506 inhibit PAN-induced podocyte apoptosis in cultured mouse podocytes in vitro.

From: Calcineurin inhibitors cyclosporin A and tacrolimus protect against podocyte injury induced by puromycin aminonucleoside in rodent models

Figure 7

(A,B) Flow cytometric analysis of the effects of CsA and FK506 pretreatment on PAN-induced apoptosis (*P < 0.05). All experiments were performed for 3 times, and the results were shown as mean ± SD. (C,D) Expression of Bax, Bcl-XL, cleaved caspase 3, and cleaved PARP after 5 μg/ml CsA (C) and 10 μg/ml FK506 (D) treatment for 24 h in PAN-treated podocytes (* < 0.05, **P < 0.01 vs PAN group). All experiments were performed for 3 times, and the results were shown as mean ± SD.

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