Table 2 Factors associated with long-term mortality in a Cox regression model * taking into account time-varying covariates.

From: Long term outcome of Aldosteronism after target treatments

 

Before match *

p

After match **

P

HR

Lower 95% CI

Upper 95% CI

HR

Lower 95% CI

Upper 95% CI

Age (in year)

1.05

1.04

1.06

<0.001

1.05

1.03

1.06

<0.001

Male gender

1.31

1.08

1.59

<0.001

    

Premorbid risk

 CKD

2.16

1.62

2.87

<0.001

    

 Congestive heart failure

1.90

1.47

2.46

<0.001

    

 Liver disease

1.87

1.44

2.42

<0.001

2.13

1.35

3.35

<0.001

 Coronary artery disease

1.90

1.30

2.77

<0.001

    

 Dementia

1.73

1.09

2.74

<0.019

    

 Hemiplegia

2.68

1.68

4.28

<0.001

3.77

1.81

7.89

<0.001

 Diabetes Mellitus

1.42

1.16

1.73

<0.001

    

 Solid tumor

1.81

1.35

2.43

<0.001

3.39

2.15

5.37

<0.001

Time-varying covariate

 Adrenalectomy

Residual hypertension +

0.28

0.18

0.44

<0.001

0.23

0.13

0.26

<0.001

Resolved hypertension +

0.25

0.14

0.44

<0.001

0.21

0.10

0.24

<0.001

 MRA

1.15

0.91

1.45

0.237

1.53

0.19

2.59

0.110

 K supply

1.94

1.47

2.56

<0.001

1.64

1.06

2.55

0.028

  1. Abbreviations: CI, confidence interval; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; HR, hazard ratio; K, potassium; MRA, mineralocorticoid receptor antagonist.
  2. *The final model had a good validity (C-index = 0.83).
  3. **The final model had a good validity (C-index = 0.79).
  4. +Cure of hypertension is defined as no use of antihypertensive drug for at least 1 year after adrenalectomy.
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