Figure 2: Effect of SERMs on AcLDL-derived cholesterol efflux from THP-1 macrophages. | Scientific Reports

Figure 2: Effect of SERMs on AcLDL-derived cholesterol efflux from THP-1 macrophages.

From: Clinically used selective estrogen receptor modulators affect different steps of macrophage-specific reverse cholesterol transport

Figure 2

(a,b) Cells were treated with [3H]cholesterol-AcLDL and vehicle (Con, control) or the indicated concentrations of tamoxifen (TAM) and in the absence or presence of T0901317 (1 μM). The cells were washed and cholesterol efflux was measured in the presence of apoA-I (a) or HDL (b) at 8 h. (c,d) Cells were treated with [3H]cholesterol-AcLDL and vehicle (Con, control) or tamoxifen (TAM), raloxifene (RAL) or toremifene (TOR) (10 μM) and in the absence or presence of T0901317 (1 μM). Then, cells were washed and cholesterol efflux was measured in the presence of apoA-I (c) or HDL (d) at 8 h. Data are mean ± SEM of 3 or 4 independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001; •P < 0.05, ••P < 0.01 between conditions only differing in the presence of T0901317.

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