Figure 4: Effect of SERMs, ICI 182,780 and 17β-estradiol on cholesterol efflux from mouse peritoneal macrophages. | Scientific Reports

Figure 4: Effect of SERMs, ICI 182,780 and 17β-estradiol on cholesterol efflux from mouse peritoneal macrophages.

From: Clinically used selective estrogen receptor modulators affect different steps of macrophage-specific reverse cholesterol transport

Figure 4

Cells were labelled with [3H]cholesterol added in ethanol and then treated with AcLDL and vehicle (Con, control) or tamoxifen (TAM), raloxifene (RAL) or toremifene (TOR) (10 μM), or the indicated concentrations of 17β-estradiol (E2) and in the absence or presence of ICI 182,780 (1 μM). Subsequently cholesterol efflux was measured in the absence or presence of apoA-I (a) or HDL (b) at 8 h. Data are mean ± SEM of macrophages from 4 or 5 mice. Bars with different letters are statistically different (P < 0.05).

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