Figure 7: Effect of tamoxifen and raloxifene on HDL composition and ex vivo cholesterol efflux capacity. | Scientific Reports

Figure 7: Effect of tamoxifen and raloxifene on HDL composition and ex vivo cholesterol efflux capacity.

From: Clinically used selective estrogen receptor modulators affect different steps of macrophage-specific reverse cholesterol transport

Figure 7

Plasma HDL was isolated from mice fed a western-type diet for 4 weeks and treated with tamoxifen (TAM), raloxifene (RAL) or vehicle (Control) for the last 10 days. (a) Pie chart of the chemical composition of HDL. Values are mean percentages of 4 mice per group. Sectors of a given component not sharing a letter are statistically different (P < 0.05). P, protein; PL, phospholipids; EC, esterified cholesterol; FC, free cholesterol; TG, triacylglycerols. (b,c) [3H]Cholesterol-labelled and AcLDL-loaded mouse peritoneal macrophages were incubated in the absence or presence of HDL (40 μg/mL) (b) or whole plasma (1%) (c) for 8 h to measure cholesterol efflux. *P < 0.05, **P < 0.01, ***P < 0.001.

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