Figure 8: Effect of tamoxifen and raloxifene on the clearance of [3H]cholesteryl oleate-labelled HDL in mice. | Scientific Reports

Figure 8: Effect of tamoxifen and raloxifene on the clearance of [3H]cholesteryl oleate-labelled HDL in mice.

From: Clinically used selective estrogen receptor modulators affect different steps of macrophage-specific reverse cholesterol transport

Figure 8

Plasma HDL was isolated from mice fed a western-type diet for 4 weeks and treated with tamoxifen (TAM), raloxifene (RAL) or vehicle (Control) for the last 10 days. HDL were labelled with [3H]cholesteryl oleate and injected intravenously into mice at day 8 of treatment with the same SERM or vehicle as the HDL donor mice. (a) Decay curve of [3H]cholesteryl oleate-labelled HDL in serum. (b) Liver [3H]cholesterol at 48 h and excretion of total [3H]tracer, [3H]cholesterol and [3H]bile acids in feces over 48 h. Data are mean ± SEM of 4 mice per group. **P < 0.01, ***P < 0.001 versus Control; ##P < 0.01, ###P < 0.001 versus RAL.

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