Figure 9: Effect of tamoxifen and raloxifene on the hepatic expression of cholesterol transporters. | Scientific Reports

Figure 9: Effect of tamoxifen and raloxifene on the hepatic expression of cholesterol transporters.

From: Clinically used selective estrogen receptor modulators affect different steps of macrophage-specific reverse cholesterol transport

Figure 9

Mice were fed a western-type diet for 4 weeks and were treated with tamoxifen (TAM), raloxifene (RAL) or vehicle (Control, Con) for the last 10 days. (a) Gene expression analysis by real-time PCR. Data are mean ± SEM of 5 mice per group and are expressed as the relative amount of mRNA compared to the level in the control condition. (b,c) Western blot analysis of liver (b) and liver membrane fraction (c) lysates. (d) Scan densitometry quantification of protein levels of the blottings shown in (b,c). Data are mean ± SEM of the ratios between the levels of each protein and those of GAPDH or calnexin, respectively. *P < 0.05, **P < 0.01.

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