Figure 1
From: Dynamics of the formation of a hydrogel by a pathogenic amyloid peptide: islet amyloid polypeptide
IAPP and Aβ form 3D hydrogels.
(a, left panel) A 51.3 μM IAPP solution forms a gel, which contains macroscopic aggregates (inset; one example of an aggregate is circled). (middle and right panels) Morphological characterisation of the gel aggregates using SEM. (b) Rheological properties of a solution of 4 μM IAPP (left panel) or 30 μM Aβ (right panel) in water were assessed at 25 °C with a controlled displacement of 5 × 10−3 rads and a frequency of 0.5 Hz. Dynamic moduli G’ and G” as a function of time, with the insets showing G’ and G” as a function of angular frequency ω. The mean of at least three independent assays per curve is shown. Error bars represent ± SEM.
