Figure 5: Short-term plasticity is altered in all dlg mutants.

(A) Top, extract of representative traces of evoked synaptic currents showing the beginning of the responses to 150 stimuli at 20 Hz; bottom, average of the responses of WT and dlg mutants normalized to the size of the average responses at low frequency stimulation. Note the increased response of all mutants during the high frequency stimulation. (B) Quantification of the tetanic facilitation⁴³. All mutants display an increased facilitation. (C) Quantification of the tetanic augmentation (the intersection of the line fitted for the second slope) for all genotypes. Only dlgA mutant show a significant difference in the values of the augmentation. (D) Quantification of the facilitation and augmentation slopes for all genotypes. Again only dlgA mutants display significant difference. The average response pre-tetanus is calculated with 5 stimuli at 0.5 Hz. Columns represent the average ± SEM n = 6 larvae. *p < 0.05, **p < 0.01 respect to the WT.