Figure 8: Inhibition of SIRT1 decreases the deacetylation of NF-κB, FoxO1 and p53 in renal tissues.
From: Melatonin prevents acute kidney injury in severely burned rats via the activation of SIRT1
The protein levels of ac-NF-κB p65, ac-FoxO1 and ac-p53 in renal tissues were measured by western blot, which showed that the expression of SIRT1 increased in burn + melatonin group while decreased after the administration of melatonin. The acetylation of NF-κB, FoxO1 and p53 showed an opposite pattern compared to that of SIRT1. ##P < 0.05 compared to the value at the burn group, n = 8 in each group. &&P < 0.05 compared to the value at the Melatonin + burn group, $$P < 0.05 compared to the value at the Melatonin + EX527 + burn group.
