Table 1 Dysregulated miRNAs, genes and targeted pathways in MDS.
miRNA | Style | Fold change (MDS/control) | Gene symbol | Pathway |
|---|---|---|---|---|
miR-148a | Down | −7.70 | TEK | PI3K-Akt signaling pathway |
ITGA9 | PI3K-Akt signaling pathway | |||
KIT | PI3K-Akt signaling pathway | |||
HMGA2 | Transcriptional misregulation in cancer | |||
miR-145 | Down | −2.96 | HHEX | Transcriptional misregulation in cancer |
MEIS1 | Transcriptional misregulation in cancer | |||
miR-200c | Down | −2.82 | EFNA1 | PI3K-Akt signaling pathway |
KLF3 | Transcriptional misregulation in cancer | |||
miR-195 | Up | 6.04 | BDNF | MAPK signaling pathway |
CDC25B | MAPK signaling pathway | |||
DLL1 | Notch signaling pathway | |||
MRAS | MAPK signaling pathway | |||
miR-17 | Up | 3.32 | CAMK2D | Calcium signaling pathway |
miR-19a | Up | 5.85 | MAML1 | Notch signaling pathway |
SLC8A1 | Calcium signaling pathway | |||
THBS1 | Proteoglycans in cancer | |||
TNF | MAPK signaling pathway | |||
TNFRSF1B | Adipocytokine signaling pathway | |||
ACSL1 | Adipocytokine signaling pathway | |||
EDNRB | Calcium signaling pathway | |||
miR-19b | Up | 2.53 | CALM1 | Calcium signaling pathway |
TNF | Proteoglycans in cancer |
