Figure 5
From: Oxidized (non)-regenerated cellulose affects fundamental cellular processes of wound healing
pH value, mean cell growth, cell migration and matrix contraction compared to pH-lowered cell media.
(A) pH value of fibroblast cultures with pH-lowered control media compared to ORC and ONRC. A difference in pH of 10% for each measuring point was accepted for experiments. (B) Shown is the mean cell growth rate for the first and second week. Inhibition of cell proliferation for ORC and ONRC compared to pH-lowered controls in the first week, for ORC for the second week (*p < 0.05; Mann-Whitney U test). n = 12. (C) Cell migration for ORC and ONRC compared to pH-lowered controls as percentage of a cell covered area between two cell fractions. Inhibition of cell migration for ORC and ONRC compared to controls (*p < 0.05; multiple t-test with Bonferroni correction). n = 12. (D) Contraction of the extracellular matrix for ORC and ONRC compared to pH-lowered controls. ORC showed almost no difference at both measuring points compared to pH-lowered controls, whereas ONRC outlined inhibited matrix contraction. (*p < 0.05; Mann-Whitney U test). n = 12.
