Table 3 Functional Annotation Clustering of the GO terms using DAVID.

From: Cell types differ in global coordination of splicing and proportion of highly expressed genes

Functional Annotation Cluster

Enrichment Score

Number of genes

Cell types cluster with low proportion of highly expressed genes

 Regulation of neurotransmitter signaling

0.95

8

 Regulation of phosphorylation

0.94

6

 Negative regulation of gene expression

0.85

7

Cell types cluster with high proportion of highly expressed genes

 Protein transport and nuclear import

2.87

18

 Cellular metabolism

1.02

32

 Cation and pH homeostasis

1.02

3

 Cell cycle

0.81

10

 Cellular response to nutrient levels

0.78

3

 Regulation of transcription and RNA splicing

0.75

15

  1. The analysis showed differential enrichment of biological functions involved in regulating gene expression and other cellular processes in cell types clusters with low or high proportion of highly expressed genes. Minimum Enrichment Score threshold was set to 0.75. Clusters implicated in the same higher order biological process were manually merged (e.g., metabolic processes of nucleobase, alkaloid, oxidoreduction coenzyme, cellular amide and membrane lipid, were merged under Cellular Metabolism category post hoc) and the averages of their enrichment scores are shown.
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