Figure 4 | Scientific Reports

Figure 4

From: Functional regeneration of the transected recurrent laryngeal nerve using a collagen scaffold loaded with laminin and laminin-binding BDNF and GDNF

Figure 4

(a) Open and (b) closed angles between arytenoid cartilages during movement of the vocal fold. The arytenoid cartilages’ angles of the arytenoid cartilages improved over time. (a) The open angles measured 4, 8 and 12 weeks after surgery were 28.79 ± 4.63°, 31.97 ± 2.78°, 35.52 ± 3.78° of the CS+LN+LBD-BDNF+LBD-GDNF group, respectively. The open angle of the CS+LN+LBD-BDNF+LBD-GDNF group showed no significant difference compared to that of the ANG group at 4 and 8 weeks after surgery (P > 0.05); while the CS+LN+LBD-BDNF+LBD-GDNF group showed significant improvements compared to the ANG group at 12 weeks (P < 0.05). (b) The closed angles at week 4, 8 and 12 were 8.35 ± 0.46°, 8.11 ± 0.87°, 6.88 ± 0.51° of the CS+LN+LBD-BDNF+LBD-GDNF group, respectively. Twelve weeks after surgery, the CS+LN+LBD-BDNF+LBD-GDNF group showed markedly smaller closed angle compared to the ANG group (P < 0.05), although the angle remained worse than that of the Sham group (P < 0.05). n = 30. *P < 0.05.

Back to article page