Figure 5: The latency and amplitude of the right PCA and TA muscles in the above groups. | Scientific Reports

Figure 5: The latency and amplitude of the right PCA and TA muscles in the above groups.

From: Functional regeneration of the transected recurrent laryngeal nerve using a collagen scaffold loaded with laminin and laminin-binding BDNF and GDNF

Figure 5

In all experimental groups, response latencies decreased and amplitudes increased from 4 to 12 weeks after surgery, although none of the groups showed responses at week 12 that were comparable to those of the Sham group (p < 0.05). (a) The latencies of the right PCA were significantly restored in the CS+LN+LBD-BDNF+LBD-GDNF group compared to those of the CS+LN+LBD-BDNF or CS+LN+LBD-GDNF group from week 4 to week 12 (P < 0.05). The latencies were shorter in the ANG group than in the CS+LN+LBD-BDNF or CS+LN+LBD-GDNF group from week 4 to week 8 (P < 0.05) and the latencies of the CS+LN+LBD-BDNF+LBD-GDNF group were shorter than those of the ANG group at week 12 (P < 0.05). (b) The amplitudes of the right PCA were significantly restored in the ANG group compared to those of the CS+LN+LBD-BDNF or CS+LN+LBD-GDNF group from week 4 to week 8 (P < 0.05). The amplitudes were much higher in the CS+LN+LBD-BDNF+LBD-GDNF group than in the CS+LN+LBD-BDNF or CS+LN+LBD-GDNF group at all time points after surgery (P < 0.05). (c) The latencies of the right TA were significantly restored in the CS+LN+LBD-BDNF+LBD-GDNF group compared to those of the CS+LN+LBD-GDNF group from week 4 to week 12 (P < 0.05). The latencies of the CS+LN+LBD-BDNF group showed significant differences compared to those of the CS+LN+LBD-BDNF+LBD-GDNF group, except for week 8. The latencies were shorter in the ANG group than in the CS+LN+LBD-BDNF or CS+LN+LBD-GDNF group from week 4 to week 8 (P < 0.05). Further, the differences were not significant between the ANG group and the CS+LN+LBD-BDNF or CS+LN+LBD-GDNF group. (d) The amplitudes of the right TA were significantly restored in the ANG group compared to those of the CS+LN+LBD-BDNF or CS+LN+LBD-GDNF group from week 4 to week 8 (P < 0.05). The amplitudes were much higher in the CS+LN+LBD-BDNF+LBD-GDNF group than in the CS+LN+LBD-GDNF or CS+LN+LBD-GDNF group at all time points (P < 0.05). n = 30. *P < 0.05.

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