Figure 6: Detection of BDNF and GDNF expression in the larynx. | Scientific Reports

Figure 6: Detection of BDNF and GDNF expression in the larynx.

From: Functional regeneration of the transected recurrent laryngeal nerve using a collagen scaffold loaded with laminin and laminin-binding BDNF and GDNF

Figure 6

(a,c) Detection of BDNF expression in the laryngeal by Western blotting analysis. (b,d) Detection of GDNF expression in the laryngeal by Western blotting analysis. (c) Expression of BDNF tended to increase from 4 to 12 weeks after surgery, except for the CS+LN+LBD-BDNF and CS+LN+LBD-BDNF+LBD-GDNF groups. BDNF expression was markedly higher in the CS+LN+LBD-BDNF, CS+LN+LBD-GDNF or CS+LN+LBD-BDNF+LBD-GDNF group than in the Sham group at all time points (P < 0.05). While BDNF expression in the CS+LN+LBD-BDNF group was higher than in the CS+LN+LBD-BDNF+LBD-GDNF group at week 4 (P < 0.05), BDNF expression in the CS+LN+LBD-BDNF+LBD-GDNF group was higher than in the CS+LN+LBD-BDNF group at weeks 8 and 12 (P < 0.05). (d) Expression of GDNF tended to increase from 4 to 12 weeks after surgery, except for the CS+LN+LBD-GDNF and CS+LN+LBD-BDNF+LBD-GDNF groups. GDNF expression was markedly higher in the CS+LN+LBD-BDNF, CS+LN+LBD-GDNF or CS+LN+LBD-BDNF+LBD-GDNF group than in the Sham group at all time points (P < 0.05). GDNF expression in the CS+LN+LBD-GDNF group was higher than in the CS+LN+LBD-BDNF+LBD-GDNF group at week 4 (P < 0.05), while this pattern was reversed at weeks 8 and 12 (P < 0.05). n = 30. *P < 0.05.

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