Figure 7 | Scientific Reports

Figure 7

From: Functional regeneration of the transected recurrent laryngeal nerve using a collagen scaffold loaded with laminin and laminin-binding BDNF and GDNF

Figure 7

BDNF (a) and GDNF (b) mRNA expression in the right recurrent laryngeal nerve by real-time PCR. (a) BDNF mRNA expression increased over time in all experimental groups. Although mRNA expression in the CS+LN+LBD-BDNF group was markedly lower than in the ANG group at weeks 4 and 8 (P < 0.05), this pattern was reversed at week 12 (P < 0.05). Furthermore, BDNF expression was markedly lower in the CS+LN+LBD-BDNF group than in the CS+LN+LBD-BDNF+LBD-GDNF group at all time points (P < 0.05). (b) GDNF mRNA expression increased over time in all experimental groups. GDNF mRNA was higher in the CS+LN+LBD-GDNF and CS+LN+LBD-BDNF+LBD-GDNF groups than in the ANG group at week 12 (P < 0.05). Furthermore, GDNF expression was much lower in the CS+LN+LBD-GDNF group than in the CS+LN+LBD-BDNF+LBD-GDNF group at all time points after surgery (P < 0.05). n = 15. *P < 0.05.

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