Figure 8: Transmission electron microscopy of the middle segment of the regenerated nerve at 12 weeks after surgery. | Scientific Reports

Figure 8: Transmission electron microscopy of the middle segment of the regenerated nerve at 12 weeks after surgery.

From: Functional regeneration of the transected recurrent laryngeal nerve using a collagen scaffold loaded with laminin and laminin-binding BDNF and GDNF

Figure 8

(a), the Sham group; (b), the ANG group; (c), the CS group; (d), the CS+LN group; (e), the CS+LN+LBD-BDNF group; (f), the CS+LN+LBD-GDNF group; (g), the CS+LN+LBD-BDNF+LBD-GDNF group. Myelinated nerve fibre cross sectional area (h) and myelin sheath thickness (i) were quantitatively evaluated and statistically analyzed. (h) Myelinated nerve fibre cross sectional area of all experimental groups increased with time. The area was higher in the CS+LN+LBD-BDNF+LBD-GDNF group than in the CS+LN+LBD-BDNF or CS+LN+LBD-GDNF group at all time points (P < 0.05), and higher than in the ANG group at week 12 (P < 0.05). (i) Myelin sheath thickness of all experimental groups increased with time. The thickness was thicker in the CS+LN+LBD-BDNF+LBD-GDNF group than in the CS+LN+LBD-BDNF or CS+LN+LBD-GDNF group (P < 0.05), and there was a negligible increase in the ANG group compared to the CS+LN+LBD-BDNF+LBD-GDNF group at all time points (P < 0.05). Scale bar = 2 μm. *P < 0.05.

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