Table 4 Associations of virological responses with SCARB1 genotypes in 156 chronic hepatitis C patients receiving pegylated interferon plus ribavirin therapy.
Virological response, n(%) | rs10846744 | P value | ||
|---|---|---|---|---|
CC genotype | CG genotype | GG genotype | ||
SVR | 42(71.2) | 61(84.7) | 15(60.0) | 0.028 |
Non-SVR | 17(28.8) | 11(15.3) | 10(40.0) | |
cEVR/pEVR | 49/4(90.7/7.4) | 65/4(92.9/5.7) | 20/2(83.3/8.3) | 0.435 |
Non-EVR | 1(1.9) | 1(1.4) | 2(8.3) | |
RVR | 38(64.4) | 55(76.4) | 17(68.0) | 0.312 |
Non-RVR | 21(35.6) | 17(23.6) | 8(32.0) | |
EOTR | 56(96.6) | 71(98.6) | 23(95.8) | 0.665 |
Non-EOTR | 2(3.5) | 1(1.4) | 1(4.2) | |
rs10846744 | ||||
rs8099917 GG/GT genotype | CC & CG genotype | GG genotype | ||
SVR | 8(72.7) | 0(0) | 0.007 | |
Non-SVR | 3(27.3) | 5(100) | ||
rs5888 | ||||
GG genotype | AG genotype | AA genotype | ||
SVR | 65(75.6) | 44(74.6) | 9(90.0) | 0.562 |
Non-SVR | 21(24.4) | 15(25.4) | 1(10.0) | |
cEVR/pEVR | 77/4(91.7/4.8) | 49/4(92.5/7.6) | 8/1(80.0/10.0) | 0.350 |
Non-EVR | 3(3.6) | 0(0) | 1(10.0) | |
RVR | 61(70.9) | 40(67.8) | 9(90.0) | 0.359 |
Non-RVR | 25(29.1) | 19(32.2) | 1(10.0) | |
EOTR | 82(96.5) | 57(98.3) | 10(100.0) | 0.695 |
Non-EOTR | 3(3.5) | 1(1.7) | 0(0) | |
rs3782287 | ||||
GG genotype | AG genotype | AA genotype | ||
SVR | 79(76.7) | 36(75.0) | 2(50) | 0.474 |
Non-SVR | 24(23.3) | 12(25.0) | 2(50) | |
cEVR/pEVR | 90/5(91.8/5.1) | 39/5(86.7/11.1) | 4/0(100/0) | 0.692 |
Non-EVR | 3(3.1) | 1(2.2) | 0(0) | |
RVR | 77(74.8) | 29(60.4) | 3(75.0) | 0.195 |
Non-RVR | 26(25.2) | 19(39.6) | 1(25.0) | |
EOTR | 99(98.0) | 46(95.8) | 4(100) | 0.697 |
Non-EOTR | 2(2.0) | 2(4.2) | 0(0) | |
