Figure 2: Expression of granzyme B, IL-17F and TNF-α in MAIT cells. | Scientific Reports

Figure 2: Expression of granzyme B, IL-17F and TNF-α in MAIT cells.

From: Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling

Figure 2

(A) Representative flow plots showing expression of granzyme B in MAIT cells from peripheral blood (PB) and tuberculous pleural effusion (PE) in the absence of antigen stimulation. (B) MAIT cells from tuberculous pleural effusions had similar expression of granzyme B compared with those from peripheral blood in the absence of antigen stimulation. (C) Representative flow plots showing expression of granzyme B in MAIT cells from peripheral blood (PB) and tuberculous pleural effusion (PE) after Mtb antigen stimulation. (D) MAIT cells from tuberculous pleural effusions had much higher expression of granzyme B than those from peripheral blood after stimulation with Mtb lysates. (E) Representative flow plots showing expression of IL-17F in MAIT cells from peripheral blood (PB) and tuberculous pleural effusion (PE) after Mtb antigen stimulation. (F) MAIT cells from tuberculous pleural effusions had significantly higher expression of IL-17F than from peripheral blood. (G) Representative flow plots showing expression of TNF-α in MAIT cells. (H) TNF-α expression in MAIT cells did not show significant difference between the two groups. Horizontal bars in the scatter plots indicate medians. The nonparametric Mann-Whitney test was used for statistical analysis between groups in Fig. 2B,D,F,H.

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