Figure 8: Blockade of γc and IL-2Rβ receptors resulted in reduced immune response of MAIT cells from tuberculous pleural effusions. | Scientific Reports

Figure 8: Blockade of γc and IL-2Rβ receptors resulted in reduced immune response of MAIT cells from tuberculous pleural effusions.

From: Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling

Figure 8

(A) Blockade of IL-2Rα did not have significant effect on IFN-γ response in MAIT cells stimulated with Mtb lysates. (B–C) Reduced IFN-γ response in MAIT cells was observed when IL-2Rβ (B) and γc receptors (C) were blocked with antibodies respectively. (D) Blockade of both IL-2Rβ (B) and γc receptors resulted in decreased IFN-γ response in MAIT cells. (E) Blockade of IL-2Rα did not have significant effect on granzyme B production in MAIT cells. (F–G) Blockade of IL-2Rβ (F) or γc receptor (G) led to significantly reduced production of granzyme B in MAIT cells. (H) Combined blocking of both IL-2Rβ and γc receptors resulted in even more reduced production of granzyme B. The non-parametric Wilcoxon signed-rank test was used for statistical analysis.

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