Figure 9: Blockade of signaling pathways with small molecule inhibitors. | Scientific Reports

Figure 9: Blockade of signaling pathways with small molecule inhibitors.

From: Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling

Figure 9

(A–F) Representative flow plots showing IFN-γ production in Mtb-stimulated MAIT cells in the presence of solvent DMSO (A), or small molecule inhibitors to JNK1/2/3 (B), NF-κB (C), p38 (D), PI3K (E), or STAT3/STAT5 (F). (G) Inhibition effect of small molecule inhibitors on IFN-γ production in Mtb-stimulated MAIT cells from tuberculous pleural effusions (n = 8). The Friedman’s test (p = 0.0004), followed by Dunn’s multiple comparison test was used for statistical analysis among groups. **p < 0.01.

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