Figure 4: Brain and peripheral tissue distributions of 125I-PrPSc after p.o. administration. | Scientific Reports

Figure 4: Brain and peripheral tissue distributions of 125I-PrPSc after p.o. administration.

From: Prions efficiently cross the intestinal barrier after oral administration: Study of the bioavailability, and cellular and tissue distribution in vivo

Figure 4

(A) Time-courses of TCA precipitable 125I-PrPSc in diverse tissues. Tissue levels showed similar time-profile seen in whole blood. Brain levels of 125I-PrPSc peaked at 3 h, and other time points were too low to be accurately measured. (B) The volumes of distribution of 125I-PrPSc represent the uptake of 125I-PrPSc over time with regard of tissue vascular space. Dashed lines indicate vascular space in each tissue estimated separately by i.v. injection of 125I-albumin. It is of note that tissue vascular space was similar to that obtained in our previous study 20. Each tissue persistently showed 9–10 times higher 125I-PrPSc distribution compared to its vascular space. Mean values with standard error are presented (n = 4). ID: injected dose.

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