Table 1 The shared genes of CVDs and GIDs.
Gene | Gene name | Types of CVDs | Types of GIDs |
|---|---|---|---|
Symbol | |||
ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | Heart Defects, Congenital | Gastroesophageal Reflux |
ACE | angiotensin I converting enzyme | Heart Failure, Cardiovascular Diseases | Stomach Neoplasms |
ADRB1 | adrenoceptor beta 1 | Heart Failure, Cardiovascular Diseases | Stomach Neoplasms |
ADRB2 | adrenoceptor beta 2, surface | Heart Failure | Stomach Neoplasms |
AHR | aryl hydrocarbon receptor | Heart Defects, Congenital; Heart diseases | Stomach Neoplasms |
ALB | albumin | Heart Diseases; Heart Failure; Cardiovascular Diseases | Stomach Neoplasms |
APEX1 | APEX nuclease (multifunctional DNA repair enzyme) 1 | Heart Diseases | Stomach Neoplasms |
AVP | arginine vasopressin | Heart Failure | Gastrointestinal Hemorrhage |
CAT | catalase | Heart Failure | Stomach Ulcer |
CSF2 | colony stimulating factor 2 (granulocyte-macrophage) | Heart Failure | Gastrointestinal Hemorrhage |
CSF3 | colony stimulating factor 3 (granulocyte) | Heart Failure; Heart Diseases | Gastrointestinal Diseases |
CYP2C19 | cytochrome P450, family 2, subfamily C, polypeptide 19 | Cardiovascular Diseases | Gastroesophageal Reflux |
EDN1 | endothelin 1 | Heart Failure; Cardiovascular Diseases; Heart Defects, Congenital; Cardiovascular Abnormalities; Cardiovascular disease, unspecified; Ischemic heart disease | Gastrointestinal Diseases |
F2R | coagulation factor II (thrombin) receptor | Cardiovascular Disorders | Stomach Neoplasms |
GCG | glucagon | Heart Failure; Heart Diseases | Stomach Diseases |
GDF15 | growth differentiation factor 15 | Heart Failure; Cardiovascular disease, unspecified | Gastrointestinal Neoplasms |
GHRL | ghrelin/obestatin prepropeptide | Heart Failure | Stomach Ulcer |
GHSR | Cardiovascular disease, unspecified | Gastrointestinal Diseases and Disorders, miscellaneous | |
HMOX1 | heme oxygenase (decycling) 1 | Heart Failure; Cardiovascular disease, unspecified | Stomach Neoplasms; Gastroparesis |
HSPB1 | heat shock 27 kDa protein 1 | Heart Failure | Stomach Neoplasms |
IL1B | interleukin 1, beta | Heart Failure; Heart Valve Diseases | Stomach Ulcer; Stomach Neoplasms; Gastritis, Atrophic |
IL6 | interleukin 6 | Heart Failure | Stomach Neoplasms |
MT2A | metallothionein 2A | Heart Diseases | Stomach Neoplasms |
MTHFR | methylenetetrahydrofolate reductase (NAD(P)H) | Cardiovascular Diseases; Heart Defects, Congenital | Stomach Neoplasms; |
NOS2 | nitric oxide synthase 2, inducible | Heart Failure, Cardiovascular Abnormalities | Stomach Ulcer |
NOS3 | nitric oxide synthase 3 (endothelial cell) | Cardiovascular Diseases; Heart Failure | Stomach Ulcer, Stomach Neoplasms |
NRG1 | neuregulin 1 | Heart Failure | Stomach Ulcer |
PLAU | plasminogen activator, urokinase | Heart Rupture, Post-Infarction | Stomach Neoplasms |
POMC | proopiomelanocortin | Heart Failure | Gastrointestinal Diseases |
PPARG | peroxisome proliferator-activated receptor gamma | Ischemic heart disease | Stomach Neoplasms |
PTGS1 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | Heart Failure | Stomach Ulcer |
PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Cardiovascular Diseases; Heart Failure | Stomach Ulcer; Stomach Neoplasms |
PYCARD | PYD and CARD domain containing | Heart Valve Diseases | Stomach Neoplasms |
RELA | Cardiovascular disease, unspecified | Gastric cancer | |
SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | Heart Failure | Stomach Neoplasms |
SOD2 | superoxide dismutase 2, mitochondrial | Heart Failure | Stomach Neoplasms |
TNF | tumor necrosis factor | Congestive heart failure | Stomach Ulcer; Stomach Neoplasms |
VEGFA | vascular endothelial growth factor A | Heart Diseases; Heart Failure | Stomach Ulcer |
ACHE | Acetylcholinesterase | Heart Failure | Stomach Tumor |
AR | Androgen Receptor | Atherosclerosis | Gastric Cancer |
CYP2A6 | Cytochrome P450 2A6 | Cardiovascular Disease | Gastric Carcinoma |
ESR1 | Estrogen Receptor | Ischemia Reperfusion Injury | Gastric Cancer |
GLO1 | Glyoxalase I | Diabetic Cardiomyopathy | Gastric Cancer |
MMP9 | Matrix metalloproteinase 9 | Heart Failure | Gastric Carcinoma |
NR3C1 | Glucocorticoid receptor | Coronary Heart Disease | Gastric Cancer |
PLA2G2A | Phospholipase A2 group IIA | Atherosclerosis | Gastric Cancer |
PLK2 | Polo-Like Kinase 2 | Myocardial Infarction | Stomach Tumor |
