Figure 7
From: Identification of mutations through dominant screening for obesity using C57BL/6 substrains
Hypothalamic neuropeptide gene expression in three mouse models of obesity.
(a) Quantitation of hypothalamic neuropeptide gene expression in Sim1+/+ (n = 9), Sim1M136K/+ (n = 9), Mc4r+/+ (n = 9), Mc4rY41X/+ (n = 9) and high-fat-diet-induced obesity (DIO) (n = 9) mice and in mice fed a regular chow diet (n = 9). Values shown are expressed relative to the average of the control groups for each comparison. (b) Altered profiles of neuropeptide gene expression of the three models of mouse obesity. *p < 0.05, **p < 0.01, ***p < 0.001, two-tailed t-test with Bonferroni correction for multiple comparisons. Data are shown as the mean + s.e.m.
