Figure 2
From: Deep sexual dimorphism in adult medaka fish liver highlighted by multi-omic approach
Metabolomics of male and female medaka livers by 1H NMR.
Principal component analysis (PCA) performed with the quantification values of the 237 metabolites detected by Batman’ R package algorithm (Supplementary Table S2) from the 18 males and 18 female individual NMR spectra (A). Volcano plot representation of the 237 metabolites according to female/male fold change average and significance of the differences (|log2 FC| > 1 corresponding to |FC| > 2 and log10 Pvalue < 1.3 corresponding to Pvalue < 0.05) (B). Female and male over-represented metabolites are determined with positive and negative significant FC (F/M) values and are shown in red and blue, respectively and are represented with darker colours when metabolite presenting VIP values are superior to 1, according to PLS-DA analysis. Top-25 lists of the putative annotations of male- and female-representative metabolites (C and D, respectively).
