Figure 6
From: Deep sexual dimorphism in adult medaka fish liver highlighted by multi-omic approach
Global proteomic effects of the different hepatotoxic cyanobacterial extract exposures (CHT1-3) on medaka fish liver.
Venn’s diagram (A) and heatmap representation (B) of proteinaceous dysregulation investigated by iTRAQ quantitative proteomic approach for both males and females. Samples are normalized according to male and female controls and significance of protein dysregulation was settled at |log2FC| > 0.25. Main metabolic categories of dysregulated proteins in males, females or in both sexes were determined according to Metaboanalyst 3.0 molecular pathway searches (Supplementary Table S5). Down-regulated proteins are indicated in yellow, up-regulated proteins in blue and missing values in grey. Clustering was performed according to Pearson’s correlation coefficient values.
