Figure 4: Transplantation of post-high fat feeding microbiota has no effect on body weight of mice.
From: High fat diet drives obesity regardless the composition of gut microbiota in mice
(a) The design of the experiment is illustrated. Briefly, mice were challenged with a HF diet for 10 weeks and a responder (R) and non-responder (N) were selected as microbiota donors. The caecal microbiota was transplanted to two groups of germfree mice and recipients were fed the same high fat diet for 10 weeks. (b) Selection of donors was based on total weight gain and 6 hour fasting blood glucose concentration. The parameters of the donors are indicated in a correlation graph indicating the opposite physiological characteristics of the donors. Body weight (c) and feed efficiency (d) of microbiota donor and recipients (NR and RR) are shown. Unpaired t-tests were perform to compare PL-R and PO-R mice. Data are mean ± s.e.m., n = 12/group. Comparison of NR and RR microbiota after 10 weeks HF feeding was performed using LDA effect size (LEfSe). The red area indicates the over-abundance in NR microbiota where the green area indicated the over-abundance in RR microbiota (e).
