Figure 5
Strong conservation of the replication timing between the duplicated homologous chromosomes.
Telomeres of both arms (p/q) of the two duplicated homologous chromosomes (orange) are more synchronous than those of the three homologous chromosomes (green) for both chromosomes 6 and 16 during the entire S-phase in TP15.5 PD523. The two duplicated homologs of chromosome 6 can be distinguished by SV40 hybridization (the two duplicated chromosomes 6 out of the three are labeled by the SV40 plasmid, cf. supplementary data 2). The two duplicated homologous of chromosomes 16 can be distinguished by the F 7501 subtelomeric probe (one of the three chromosomes 16 is labeled by this probe and the two duplicated chromosomes are not). Telomere replication for duplicated homologous chromosomes and for the three homologous chromosomes is not random (chi-squared test). The test of the two duplicated chromosomes was much stronger than for the three homologous chromosomes (p-value ≈ 10-10 Vs. 10-4 on average), confirming that telomere replication for the duplicated homologous chromosomes is more synchronous than that for the three homologous chromosomes.
