Figure 1 | Scientific Reports

Figure 1

From: Local and Circulating Endothelial Cells Undergo Endothelial to Mesenchymal Transition (EndMT) in Response to Musculoskeletal Injury

Figure 1

VeCadherin-cre-labeled mice suggest EndMT in a model of trauma-induced HO.

(A) Burn/tenotomy results in trauma-induced HO (tHO) at the tendon transection site; (B) RNA Seq shows up-regulated transcript levels for Tgfβ, fibroblast growth factor (FGF), Snai1 and Twist1; (C) VeCadherin-cre/tdTomato lineage-tracing mice show presence of tdTomato + cells in the fibroproliferative region expressing PDGFRα, Osterix (OSX) but not SOX9 or Aggrecan (ACAN); D) VeCadherin-cre/tdTomato lineage-tracing mice show presence of tdTomato+ cells in the cartilage region expressing PDGFRα, Osterix (OSX), SOX9 and Aggrecan (ACAN).

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