Figure 3 | Scientific Reports

Figure 3

From: Local and Circulating Endothelial Cells Undergo Endothelial to Mesenchymal Transition (EndMT) in Response to Musculoskeletal Injury

Figure 3

(A) Schematic showing cell transplantation experiments; (B) FACS sorting of endothelial cells (tdTomato+/CD31+/CD45−) from the hindlimb musculature of uninjured VeCadherin-cre/tdTomato + mice; (C) tdTomato + cells are present within the cartilage anlagen and express Osterix (OSX); (D) tdTomato + cells are present within the cartilage anlagen and express PDGFRα; (E) tdTomato + cells are present within the cartilage anlagen and express SOX9; (F) tdTomato + cells are present within the cartilage anlagen and express Aggrecan (ACAN); (G) H&E showing histologic character of tdTomato + cells undergoing EndMT with chondrocyte appearance and OSX expression as in (C).

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