Figure 6 | Scientific Reports

Figure 6

From: miR-564 acts as a dual inhibitor of PI3K and MAPK signaling networks and inhibits proliferation and invasion in breast cancer

Figure 6

Expression of AKT2, GNA12, GYS1 and SRF in combination correlates with PI3K pathway activation in breast cancer patients and predicts survival.

(A) Correlation analysis of AKT phosphorylations (S473 and T308) with combined mRNA expression levels of miR-564 target genes in 750 breast cancer samples from TCGA dataset. (B) PRAS40 phosphorylation (T246) and its correlation with mRNA levels of miR-564 target genes in 750 breast cancer samples from TCGA dataset. (C) Protein level correlation of p27 with mRNA levels of target genes in 750 breast cancer patients. (D) Correlation of p27 phosphorylation levels at two different sites (T157 and T198) with mRNA expression levels of targets in 750 breast cancer patient samples. (E) Survival analysis of breast cancer patients estimated by Kaplan Meier survival curve with high (red) and low (blue) expression of miR-564 target genes in combination using GSE3494 (n = 234) and GSE22220 (n = 216) datasets.

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