Table 3 Hazard ratios(HR) with 95% confidence intervals(CI) for breast cancer incidence according to psychological item responses.

Response to questions	No. of women	Observed person-years	No. of cases	Age-adjusted		Multivariate-adjusted^a
Response to questions	No. of women	Observed person-years	No. of cases	HR	95%CI	HR	95%CI
Having “ikigai”
Disagree	2,068	25,355	15	1.00		1.00
Neither	14,505	185,952	114	1.03	0.61–1.77	1.02	0.59–1.75
Agree	9,770	125,897	61	0.80	0.46–1.41	0.77	0.43–1.37
Agree strongly	2,755	34,952	19	0.90	0.46–1.78	0.81	0.41–1.62
Decisiveness
Disagree	3155	38,349	18	1.00		1.00
Neither	19,206	247,330	140	1.19	0.73–1.94	1.18	0.72–1.94
Agree	6,737	86,477	51	1.21	0.71–2.08	1.07	0.62–1.85
Ease of anger
Disagree	4,171	51,898	22	1.00		1.00
Neither	21,013	270,672	163	1.38	0.88–2.16	1.41	0.91–2.21
Agree	3,914	49,585	24	1.08	0.61–1.94	0.98	0.55–1.76
Perceived stress
Disagree	4,730	57,634	28	1.00		1.00
Neither	18,208	235,880	128	1.11	0.74–1.67	1.21	0.80–1.82
Agree	3,214	38,859	33	1.66	1.00–2.76	1.71	1.02–2.85
Agree strongly	2,946	39,782	20	1.00	0.56–1.78	1.00	0.56–1.78

^aAdjusted for age, study area, educational level, family history of breast cancer, age at menarche, age at menopause, age at first birth, parity, use of exogenous female hormone, alcohol drinking, consumption of green leafy vegetables, daily walking, exercise, sedentary work, height and body mass index

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