Table 2 Function of the top 10 subnetworks for AD, prostate cancer, Parkinson’s disease, and T2D.
From: Discover the network mechanisms underlying the connections between aging and age-related diseases
Alzheimer’s disease | FDR | Prostate cancer | FDR |
|---|---|---|---|
GO0019897_extrinsic component plasma membrane | 2.9E-15 | GO0045639_positive regulation myeloid cell differentiation | 3.8E-08 |
GO0031331_positive regulation cell catabolic process | 2.3E-12 | GO0010564_regulation of cell cycle process | 4.1E-08 |
GO0009260_ribonucleotide biosynthetic process | 1.8E-10 | hsa04910_Insulin signaling pathway | 3.2E-07 |
GO1903364_positive regulation of cellular protein catabolic process | 1.3E-09 | hsa04012_ErbB signaling pathway | 3.4E-07 |
GO0070374_positive regulate ERK1 & ERK2 cascade | 1.9E-09 | GO0016051_carbohydrate biosynthetic process | 3.5E-07 |
GO0071396_cellular response to lipid | 7.6E-09 | GO0045766_positive regulation of angiogenesis | 6.1E-07 |
GO0009165_nucleotide biosynthetic process | 1.1E-08 | GO0002763_positive regulation myeloid leukocyte differentiation | 7.2E-07 |
GO1903426_regulation of reactive oxygen species biosynthetic process | 1.1E-08 | GO0001936_regulation endothelial cell proliferation | 1.3E-06 |
GO0050921_positive regulation chemotaxis | 1.4E-08 | GO0044042_glucan metabolic process | 1.4E-06 |
GO0031344_regulation cell projection organization | 1.4E-08 | hsa04062_Chemokine signaling pathway | 1.5E-06 |
Parkinson’s disease | FDR | type 2 diabetes | FDR |
GO0044708_single-organism behavior | 3.4E-08 | GO0005125_cytokine activity | 4.5E-10 |
GO0010506_regulation of autophagy | 9.8E-08 | GO0032943_mononuclear cell proliferation | 1.9E-09 |
GO1903146_regulation mitochondrion degradation | 5.7E-07 | GO0046651_lymphocyte proliferation | 3.9E-09 |
hsa05016_Huntington’s disease | 2.1E-06 | GO0042100_B cell proliferation | 4.9E-09 |
hsa05010_Alzheimer’s disease | 2.9E-06 | GO0070665_positive regulation leukocyte proliferation | 4.5E-08 |
GO0022900_electron transport chain | 5.0E-06 | GO0042471_ear morphogenesis | 5.3E-08 |
GO0022904_respiratory electron transport chain | 6.0E-06 | GO0042472_inner ear morphogenesis | 9.8E-08 |
hsa05012_Parkinson’s disease | 3.1E-05 | GO2000379_positive regulation of reactive oxygen species metabolic process | 1.7E-07 |
GO0046128_purine ribonucleoside metabolic process | 3.3E-05 | GO2000147_positive regulation of cell motility | 2.9E-07 |
GO0044455_mitochondrial membrane part | 3.4E-05 | GO0070661_leukocyte proliferation | 3.2E-07 |
