Figure 5
Kidney Wnt4 is upregulated in MCD patients with early AKI, similar to the expression of KIM-1.
(a) Representative light microscopy images of HE, PAS and Masson-stained sections of the renal tissue in MCD patients with or without tubular injury (magnification, 200x). Scale bar, 100 μm. (b) Renal tubular injury score from HE staining. (c) Quantification of the fibrotic area from Masson staining. (d) Immunohistochemistry of kidney Wnt4 and KIM-1 (magnification, 200x). Scale bar, 100 μm. (e) Quantification of immunohistochemistry for Wnt4. (f) Quantification of immunohistochemistry for KIM-1. (g) Correlation between kidney Wnt4 expression and tubular injury in MCD patients. (h) Correlation between kidney Wnt4 and KIM-1 expression by immunohistochemistry. ***P < 0.001 versus MCD only.
