Figure 6
Urinary Wnt4 is elevated in MCD patients with early AKI but normal serum creatinine, similar to KIM-1.
(a) Western blot analysis and quantification of urinary Wnt4 excretion in MCD patients with or without tubular injury. (b) Western blot analysis and quantification of urinary KIM-1 excretion in MCD patients with or without tubular injury. (c) ELISA analysis of urinary Wnt4 normalized to uCr in each group. (d) ELISA analysis of urinary KIM-1 normalized to uCr in each group. (e) Correlation between urinary Wnt4 level and tubular injury. (f) Correlation between urinary Wnt4 excretion and kidney Wnt4 expression (by immunochemical staining). (g) Correlation between urinary Wnt4 and KIM-1 excretion. Cropped blots are shown (full-sized blots are presented in Supplementary Fig. S5). *P < 0.05, **P < 0.01, versus MCD only.
