Table 2 Proportional hazard model for recurrence free survival and overall survival prediction.

From: Dectin-1 predicts adverse postoperative prognosis of patients with clear cell renal cell carcinoma

Variables

RFS (n = 265)

OS (n = 290)

Base model

Bootstrap validate model*

Base model

Bootstrap validate model*

HR (95%CI)

P-value†

HR (95%CI)

P-value†

HR (95%CI)

P-value†

HR (95%CI)

P-value†

Pathological T stage

 

<0.001

 

0.001

 

<0.001

 

0.001

 pT1

Reference

—

Reference

—

Reference

—

Reference

—

 pT2 vs pT1

2.579 (1.170–5.681)

0.019

2.790 (1.080–6.760)

0.035

2.691 (1.331–5.443)

0.006

2.759 (1.185–6.341)

0.013

 pT3 vs pT1

3.090 (1.786–5.346)

<0.001

3.114 (1.329–5.590)

0.004

2.986 (1.791–4.977)

<0.001

3.037 (1.675–5.635)

0.001

 pT4 vs pT1

11.864 (3.743–37.605)

<0.001

13.183 (1.000–64.264)

0.001

5.740 (1.630–20.209)

0.007

5.737 (0.000–72.675)

0.054

Distant metastasis

 Yes vs No

—

—

—

—

4.089 (2.121–7.885)

<0.001

4.787 (1.822–15.379)

0.008

Fuhrman grade

 

<0.001

 

<0.001

 

0.001

 

0.001

 1–2

Reference

—

Reference

—

Reference

—

Reference

—

 3 vs 1–2

2.744 (1.502–5.012)

0.001

2.751 (1.023–5.414)

0.002

2.471 (1.414–4.317)

0.001

2.588 (1.439–4.563)

0.002

 4 vs 1–2

5.675 (1.648–19.538)

0.006

5.906 (1.000–17.868)

0.001

4.782 (1.409–16.227)

0.012

5.328 (2.125–18.634)

0.004

Necrosis

 Present vs Absent

2.182 (1.211–3.930)

0.009

2.232 (1.012–4.477)

0.011

2.033 (1.146–3.607)

0.015

2.136 (1.136–4.242)

0.025

ECOG PS

 

0.003

 

0.031

 

0.003

 

0.010

 0

Reference

—

  

Reference

—

Reference

—

 1 vs 0

1.892 (1.093–3.273)

0.023

1.908 (1.005–3.636)

0.039

2.236 (1.383–3.615)

0.001

2.293 (1.302–4.047)

0.004

 2 vs 0

3.954 (1.374–11.379)

0.011

3.304 (1.104–12.858)

0.025

2.658 (0.990–7.142)

0.052

2.477 (0.482–9.281)

0.104

 3 vs 0

4.142 (1.283–13.367)

0.017

5.496 (0.947–32.852)

0.097

3.193 (0.890–11.455)

0.075

2.787 (0.320–15.721)

0.101

Tumoral dectin-1

 Low vs High

2.436 (1.494–3.970)

<0.001

2.438 (1.276–4.367)

0.006

3.123 (1.961–4.976)

<0.001

3.212 (1.862–5.906)

0.001

  1. ECOG PS = Eastern Cooperative Oncology Group performance status; HR = hazard ratio; CI = confidence interval; OS = overall survival; RFS = recurrence free survival; †Data obtained from the Cox proportional hazards model, P-value <0.05 was regarded as statistically significant; *Bootstrapping with 1000 resamples were used.
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