Table 3 Comparison of the predictive accuracy of the prognostic models.

From: Dectin-1 predicts adverse postoperative prognosis of patients with clear cell renal cell carcinoma

Models

Recurrence free survival

Overall survival

C-index (95%CI)

Coefficient (95%CI)

P-value

C-index (95%CI)

Coefficient (95%CI)

P-value

Tumoral Dectin-1

0.643 (0.587–0.700)

 

0.638 (0.585 –0.691)

 

TNM

0.658 (0.600–0.716)

 

0.702 (0.648–0.757)

 

TNM + Tumoral Dectin-1

0.708 (0.650–0.767)

0.050 (0.012–0.089)

0.001

0.747 (0.694–0.800)

0.045 (0.013–0.078)

0.006

SSIGN

0.718 (0.665–0.772)

 

0.740 (0.692–0.787)

 

SSIGN + Tumoral Dectin-1

0.762 (0.708–0.815)

0.044 (0.008–0.080)

0.017

0.772 (0.723–0.821)

0.032 (−0.006–0.071)

0.093

UISS

0.713 (0.662–0.764)

 

0.723 (0.670–0.776)

 

UISS + Tumoral Dectin-1

0.760 (0.709–0.811)

0.047 (0.023–0.072)

0.010

0.763 (0.713–0.814)

0.040 (0.001–0.080)

0.050

Nomogram

0.796 (0.747–0.846)

 

0.812 (0.769–0.856)

 

Nomogram vs SSIGN

 in all patients

0.086 (0.435–0.129)

<0.001

0.072 (0.036–0.110)

<0.001

 in SSIGN low/intermediate groups

0.097 (0.049–0.146)

<0.001

0.099 (0.053–0.146)

<0.001

Nomogram vs UISS

 in all patients

0.082 (0.045–0.119)

<0.001

0.089 (0.043–0.135)

<0.001

 in UISS low/intermediate groups

0.095 (0.069–0.130)

<0.001

0.092 (0.052–0.133)

<0.001

  1. Compared the c-index with the original model without tumoral Dectin-1 expression data; Compared the c-index of nomogram with SSIGN/UISS stratification in different patient groups; C-index = concordance index; CI = confidence interval; SSIGN = Mayo clinic stage, size, grade, and necrosis score; UISS = UCLA Integrated Staging System. C-index and 95%CI were calculated from 1000 bootstrap samples to protect from overfitting.