Table 1 In vitro activities of the antimicrobial agents tested against 105 CnsKP isolates.

From: High minimum inhibitory concentration of imipenem as a predictor of fatal outcome in patients with carbapenem non-susceptible Klebsiella pneumoniae

Antimicrobial agent

MIC range (μg/mL)

MIC50a (μg/mL)

MIC90b (μg/mL)

No. (%) of isolates susceptible

Ciprofloxacin

≤0.25 to ≥4

≥4

≥4

4 (3.8)

Levofloxacin

≤0.12 to ≥8

≥8

≥8

4 (3.8)

Ampicillin-sulbactam

≥32

≥32

≥32

0 (0)

Piperacillin-tazobactam

≥128

≥128

≥128

0 (0)

Cefazolin

≥64

≥64

≥64

0 (0)

Ceftriaxone

2 to ≥64

≥64

≥64

0 (0)

Ceftazidime

16 to ≥64

≥64

≥64

0 (0)

Cefepime

≤1 to ≥64

≥64

≥64

12 (11.4)

Amikacin

≤2 to ≥64

≤2

≥64

84 (80)

Gentamicin

≤1 to ≥16

≤1

≥16

59 (56.2)

Ertapenem

2 to ≥8

≥8

≥8

0 (0)

Imipenem

1 to ≥16

8

≥16

1 (0.9)

Colistin

≤0.5 to ≥16

≤0.5

2

93 (88.6)

Tigecycline

≤0.5 to ≥8

2

4

86 (81.9)

  1. CnsKP: carbapenem non-susceptible Klebsiella pneumoniae; MIC: minimum inhibitory concentration.
  2. aMIC50: MIC for 50% of isolates.
  3. bMIC90: MIC for 90% of isolates.