Table 3 Association Between rs4225 Variant with CHD.

From: An APOC3 3′UTR variant associated with plasma triglycerides levels and coronary heart disease by creating a functional miR-4271 binding site

SNP rs ID

Function

Population

MAF

P allele

MM

Mm

mm

Model

Crude ORs (95% CI)

Adjusted

Adjusted ORs (95% CI)

(M > m)

n, (%)

n, (%)

n, (%)

P value

rs4225

3′-UTR

Control

0.21

0.009

1891

953

138

 

1.00

 

1.00

(G > T)

CHD

0.19

1750

774

103

Additive

0.81(0.62–1.05)

0.18

0.85 (0.68–1.21)

        

Dominant

0.83 (0.64–1.07)

0.21

0.86 (0.71–1.16)

        

Recessive

0.86 (0.78–0.96)

0.009

0.89 (0.77–0.98)

  1. CHD, Coronary Heart Disease; M, major allele; m, minor allele; MAF, minor allele frequency.
  2. P allele value of allele and Crude odds ratio (95% confidence interval) were determined by a 95% two-sided χ2 test, CHD versus controls.
  3. Adjusted ORs (95% CI) and adjusted P-value were obtained with multivariate unconditional logistic regression analysis by adjusting for sex, age, smoking, hypertension, hyperlipidemia, diabetes and body mass index.
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