Figure 1

Breast Cancer tissue showing (left) high and (right) low tubule formation.
Lumen is delineated by blue lines. Tubules are delineated by orange lines, where nuclei inside these boundaries represent the tubule nuclei used in our approach. Green and red dots correspond to nuclei candidates classified as tubule or non-tubule nuclei by our DNN classifier. In the high ODX (right) image, the cells have lost their capacity to form tubules with a rounded lumen.