Figure 3
From: Tissue-specific Co-expression of Long Non-coding and Coding RNAs Associated with Breast Cancer
Validation in TCGA.
(a) Validation of mRNA expression differences in TCGA. X-axis represents Log2FC between 18 breast tumor and 18 normal tissue samples from our dataset; Y-axis represents Log2FC between 744 breast tumors and 104 adjacent normal tissue samples from TCGA dataset; 207 differentially expressed mRNAs in both datasets are shown. (b) and (c) Validation of lncRNA-mRNA co-expression in breast tumors in TCGA. Our dataset consists of 18 breast tumor samples; and TCGA dataset consists of 692 breast tumors. (b) Directions of the lncRNA-mRNA associations in two datasets were compared in 183 lncRNA-mRNA pairs identified in differential co-expression analysis; (c) Directions of the lncRNA-mRNA associations were compared in 139 lncRNA-mRNA pairs identified in dose-response co-expression analysis. Red arrows indicate positive correlations, and Green arrows indicate negative correlation between lncRNAs and mRNAs.
