Table 1 The effects of I3C, sorafenib and their combination on the gene expression of VEGF, EGFR and E-cadherin.

From: Indole-3- carbinol enhances sorafenib cytotoxicity in hepatocellular carcinoma cells: A mechanistic study

Groups

VEGF

EGFR

E-cadherin

Control

1 ± 0.00b

1 ± 0.00b

1 ± 0.00b

I3C

0.86 ± 0.12

0.85 ± 0.03a

1.18 ± 0.20b

Sorafenib

0.74 ± 0.06a

0.76 ± 0.11a

1.81 ± 0.25a

Combination

0.36 ± 0.04a,b

0.63 ± 0.00a

3.46 ± 0.14a,b

  1. Data is given as mean  ±  SD of 3 independent experiments. a or b: Significantly different from the control or sorafenib group, respectively, p < 0.05 using ANOVA followed by Tukey–Kramer as post-hoc test.
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